Gastric non-Hodgkin’s lymphoma

A 42-year-old female patient was admitted due to epigastric pain and weight loss. Her past medical history was otherwise negative apart from cigarette smoking. Her physical examination was unremarkable. C-reactive protein and erythrocyte sedimentation rate were raised up to 14.8 mg/ dL and 51 mm/h respectively, platelets were 453,000, while the remaining laboratory tests were normal. Upper gastrointestinal endoscopy revealed a well-defined polypoid mass in the fundus with a diameter of about 2 cm (Fig. 1A). A computed tomography scan followed, showing protruding irregular gastric lesions and a pancreatic mass (Fig. 1B). Histopathological examination of the gastric lesions revealed infiltration of gastric mucosa by diffuse large B-cell lymphoma (mitotic index Ki-67 60%) (Fig. 1C). The patient commenced on standard chemotherapy with good response. Extranodal non-Hodgkin’s lymphoma (NHL) may be initially seen as primary gastrointestinal (GI) lymphoma (rare) or as disseminated nodal disease secondarily involving the GI tract. Diffuse large B-cell lymphoma is the most common NHL subtype [1]. GI tract and especially the stomach is the most frequent extranodal site in NHL. Endoscopically the secondary gastric NHL might present as polypoid in ulcerative and infiltrative lesions; it can involve all parts of the stomach, usually with multifocal tumors [2,3]. Endoscopists should be aware of the diverse appearance of this neoplasm.